Cargando…

Cytotoxic Marine Alkaloid 3,10-Dibromofascaplysin Induces Apoptosis and Synergizes with Cytarabine Resulting in Leukemia Cell Death

Myeloid leukemia is a hematologic neoplasia characterized by a clonal proliferation of hematopoietic stem cell progenitors. Patient prognosis varies depending on the subtype of leukemia as well as eligibility for intensive treatment regimens and allogeneic stem cell transplantation. Although signifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spirin, Pavel, Shyrokova, Elena, Lebedev, Timofey, Vagapova, Elmira, Smirnova, Polina, Kantemirov, Alexey, Dyshlovoy, Sergey A., von Amsberg, Gunhild, Zhidkov, Maxim, Prassolov, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468638/ https://www.ncbi.nlm.nih.gov/pubmed/34564151 http://dx.doi.org/10.3390/md19090489

Ejemplares similares

Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives
por: Tryapkin, Oleg A., et al.
Publicado: (2023)

Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents
por: Zhidkov, Maxim E., et al.
Publicado: (2022)

Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
por: Zhidkov, Maxim E., et al.
Publicado: (2019)

Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles
por: Spirin, Pavel, et al.
Publicado: (2022)

Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs
por: Vagapova, Elmira, et al.
Publicado: (2021)

Publisher Correction: Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis
por: Vagapova, Elmira R., et al.
Publicado: (2021)

Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis
por: Vagapova, Elmira R., et al.
Publicado: (2021)

Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia
por: Lebedev, Timofey D., et al.
Publicado: (2019)

Immunoproteasome Activity and Content Determine Hematopoietic Cell Sensitivity to ONX-0914 and to the Infection of Cells with Lentiviruses
por: Vagapova, Elmira, et al.
Publicado: (2021)

A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes
por: Burov, Alexander, et al.
Publicado: (2021)

The Role of TAL1 in Hematopoiesis and Leukemogenesis
por: Vagapova, E. R., et al.
Publicado: (2018)

Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes
por: Lebedev, Timofey, et al.
Publicado: (2021)

Subtype of Neuroblastoma Cells with High KIT Expression Are Dependent on KIT and Its Knockdown Induces Compensatory Activation of Pro-Survival Signaling
por: Lebedev, Timofey, et al.
Publicado: (2022)

The Role of the MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation
por: Shyrokova, E. Y., et al.
Publicado: (2021)

Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1
por: Glumakova, Ksenia, et al.
Publicado: (2023)

Establishment of a FDC-P1 Murine Cell Line with Human KIT N822K Gene Overexpression
por: Vagapova, E. R., et al.
Publicado: (2020)

The Different Impact of ERK Inhibition on Neuroblastoma, Astrocytoma, and Rhabdomyosarcoma Cell Differentiation
por: Lebedev, T. D., et al.
Publicado: (2021)

Marine Compounds from the Far Eastern Organisms
por: Dyshlovoy, Sergey A., et al.
Publicado: (2023)

MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation
por: Bondarev, Nikolay, et al.
Publicado: (2022)

Transfer and Expression of Small Interfering RNAs in Mammalian Cells Using Lentiviral Vectors
por: Lebedev, T. D., et al.
Publicado: (2013)

PB1760: PREDICTION OF DRUG SENSITIVITY AND GENETIC VULNERABILITY FOR ACUTE LEUKEMIA SUBTYPES USING GRAPH OF SIGNALING PATHWAY CORRELATIONS.
por: Lebedev, Timofey, et al.
Publicado: (2023)

Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors
por: Lebedev, Timofey D., et al.
Publicado: (2022)

Plasmolipin and Its Role in Cell Processes
por: Shulgin, A. A., et al.
Publicado: (2021)

Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors
por: Spirin, Pavel, et al.
Publicado: (2017)

The Inhibitory Activity of Luzonicosides from the Starfish Echinaster luzonicus against Human Melanoma Cells
por: Malyarenko, Olesya S., et al.
Publicado: (2017)

Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
por: Serhan, Nizar, et al.
Publicado: (2020)

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
por: Dyshlovoy, Sergey A., et al.
Publicado: (2015)

Sea Anemone Heteractis crispa Actinoporin Demonstrates In Vitro Anticancer Activities and Prevents HT-29 Colorectal Cancer Cell Migration
por: Kvetkina, Aleksandra, et al.
Publicado: (2020)

New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2022)

Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

Alkaloids of fascaplysin are effective conventional chemotherapeutic drugs, inhibiting the proliferation of C6 glioma cells and causing their death in vitro
por: Bryukhovetskiy, Igor, et al.
Publicado: (2017)

Gene expression and molecular pathway activation signatures of MYCN-amplified neuroblastomas
por: Petrov, Ivan, et al.
Publicado: (2017)

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro
por: Dyshlovoy, Sergey A., et al.
Publicado: (2016)

Draft Genome Sequences of Aggregatibacter actinomycetemcomitans Strains 310a and 310b
por: May, Anthony C., et al.
Publicado: (2017)

Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine
por: Dakik, Hassan, et al.
Publicado: (2022)

Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells
por: Dyshlovoy, Sergey A., et al.
Publicado: (2014)

The Role of Autophagy in the Development of Pathological Conditions of the Body
por: Kench, U. S., et al.
Publicado: (2023)

Sun certification training guide (310-025, 310-027): Java 2 programmer and developer exams
por: Jaworski, Jamie
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_bou58c7rbnu9a2rq73pr03k15p