PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Uridine 5′-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines, but prediction of first-pass extraction from the related metabolism is not well studied. This work assesses physiologically based pharmacokinetic (PBPK) modeling as a tool for predicting intestinal metabolism...

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Detalles Bibliográficos
Autores principales: Reddy, Micaela B., Bolger, Michael B., Fraczkiewicz, Grace, Del Frari, Laurence, Luo, Laibin, Lukacova, Viera, Mitra, Amitava, Macwan, Joyce S., Mullin, Jim M., Parrott, Neil, Heikkinen, Aki T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468656/
https://www.ncbi.nlm.nih.gov/pubmed/34575401
http://dx.doi.org/10.3390/pharmaceutics13091325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468656/
https://www.ncbi.nlm.nih.gov/pubmed/34575401
http://dx.doi.org/10.3390/pharmaceutics13091325

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