Myeloid Lineage Ablation of Phlpp1 Regulates M-CSF Signaling and Tempers Bone Resorption in Female Mice

Prior work demonstrated that Phlpp1 deficiency alters trabecular bone mass and enhances M-CSF responsiveness, but the cell types and requirement of Phlpp1 for this effect were unclear. To understand the function of Phlpp1 within myeloid lineage cells, we crossed Phlpp1 floxed mice with mice harborin...

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Detalles Bibliográficos
Autores principales: Karkache, Ismael Y., Damodaran, Jeyaram R., Molstad, David H. H., Mansky, Kim C., Bradley, Elizabeth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468863/
https://www.ncbi.nlm.nih.gov/pubmed/34575866
http://dx.doi.org/10.3390/ijms22189702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468863/
https://www.ncbi.nlm.nih.gov/pubmed/34575866
http://dx.doi.org/10.3390/ijms22189702

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