Preparation of Solid Dispersions of Simvastatin and Soluplus Using a Single-Step Organic Solvent-Free Supercritical Fluid Process for the Drug Solubility and Dissolution Rate Enhancement

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO(2)) processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in Soluplus(®) (SOL) at temperatures below polymer’s glass transition. The SIM content in the SDs experimental design was kept a...

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Detalles Bibliográficos
Autores principales: Nandi, Uttom, Ajiboye, Adejumoke Lara, Patel, Preksha, Douroumis, Dennis, Trivedi, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468910/
https://www.ncbi.nlm.nih.gov/pubmed/34577546
http://dx.doi.org/10.3390/ph14090846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468910/
https://www.ncbi.nlm.nih.gov/pubmed/34577546
http://dx.doi.org/10.3390/ph14090846

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