The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line

Leflunomide, an anti-inflammatory agent, has been shown to be effective in multiple myeloma (MM) treatment; however, the mechanism of this phenomenon has not been fully elucidated. The aim of the study was to assess the role of mitochondria and dihydroorotate dehydrogenase (DHODH) inhibition in the...

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Detalles Bibliográficos
Autores principales: Adamczuk, Grzegorz, Humeniuk, Ewelina, Iwan, Magdalena, Natorska-Chomicka, Dorota, Adamczuk, Kamila, Korga-Plewko, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469018/
https://www.ncbi.nlm.nih.gov/pubmed/34577124
http://dx.doi.org/10.3390/molecules26185653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469018/
https://www.ncbi.nlm.nih.gov/pubmed/34577124
http://dx.doi.org/10.3390/molecules26185653

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