Catalytic Asymmetry in Homodimeric H(+)-Pumping Membrane Pyrophosphatase Demonstrated by Non-Hydrolyzable Pyrophosphate Analogs

Membrane-bound inorganic pyrophosphatase (mPPase) resembles the F-ATPase in catalyzing polyphosphate-energized H(+) and Na(+) transport across lipid membranes, but differs structurally and mechanistically. Homodimeric mPPase likely uses a “direct coupling” mechanism, in which the proton generated fr...

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Detalles Bibliográficos
Autores principales: Anashkin, Viktor A., Malinen, Anssi M., Bogachev, Alexander V., Baykov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469034/
https://www.ncbi.nlm.nih.gov/pubmed/34575984
http://dx.doi.org/10.3390/ijms22189820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469034/
https://www.ncbi.nlm.nih.gov/pubmed/34575984
http://dx.doi.org/10.3390/ijms22189820

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