An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease

Antibody-cytokine fusion proteins (immunocytokines) are gaining importance for cancer therapy, but those products are often limited by systemic toxicity related to the activity of the cytokine payload in circulation and in secondary lymphoid organs. Tumor necrosis factor (TNF) is used as a pro-infla...

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Detalles Bibliográficos
Autores principales: Dakhel, Sheila, Lizak, Christian, Matasci, Mattia, Mock, Jacqueline, Villa, Alessandra, Neri, Dario, Cazzamalli, Samuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469155/
https://www.ncbi.nlm.nih.gov/pubmed/34576184
http://dx.doi.org/10.3390/ijms221810020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469155/
https://www.ncbi.nlm.nih.gov/pubmed/34576184
http://dx.doi.org/10.3390/ijms221810020

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