Immunomodulatory Properties of BRAF and MEK Inhibitors Used for Melanoma Therapy—Paradoxical ERK Activation and Beyond

The advent of mitogen-activated protein kinase (MAPK) inhibitors that directly inhibit tumor growth and of immune checkpoint inhibitors (ICI) that boost effector T cell responses have strongly improved the treatment of metastatic melanoma. In about half of all melanoma patients, tumor growth is driv...

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Detalles Bibliográficos
Autores principales: Jung, Thomas, Haist, Maximilian, Kuske, Michael, Grabbe, Stephan, Bros, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469254/
https://www.ncbi.nlm.nih.gov/pubmed/34576054
http://dx.doi.org/10.3390/ijms22189890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469254/
https://www.ncbi.nlm.nih.gov/pubmed/34576054
http://dx.doi.org/10.3390/ijms22189890

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