Cargando…

Benzydamine Reverses TMexCD-TOprJ-Mediated High-Level Tigecycline Resistance in Gram-Negative Bacteria

Recently, a novel efflux pump gene cluster called tmexCD1-toprJ1 and its variants have been identified, which undermine the antibacterial activity of tigecycline, one of the last remaining options effective against multidrug-resistant (MDR) Gram-negative bacteria. Herein, we report the potent synerg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tong, Ziwen, Xu, Tianqi, Deng, Tian, Shi, Jingru, Wang, Zhiqiang, Liu, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470189/ https://www.ncbi.nlm.nih.gov/pubmed/34577607 http://dx.doi.org/10.3390/ph14090907

Ejemplares similares

Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump tmexC6D6-toprJ1b and tmexCD-toprJ Variants
por: Wang, Cheng-Zhen, et al.
Publicado: (2023)

Metformin Reverses tmexCD1-toprJ1- and tet(A)-Mediated High-Level Tigecycline Resistance in K. pneumoniae
por: Xiao, Xia, et al.
Publicado: (2022)

Emergence of a Novel Plasmid-Mediated Tigecycline Resistance Gene Cluster, tmexCD4-toprJ4, in Klebsiella quasipneumoniae and Enterobacter roggenkampii
por: Gao, Xun, et al.
Publicado: (2022)

Plasmids Shape the Current Prevalence of tmexCD1-toprJ1 among Klebsiella pneumoniae in Food Production Chains
por: Peng, Kai, et al.
Publicado: (2021)

Integrative conjugative elements mediate the high prevalence of tmexCD3-toprJ1b in Proteus spp. of animal source
por: Peng, Kai, et al.
Publicado: (2023)

Coexistence of tmexCD-toprJ, bla(NDM-1), and bla(IMP-4) in One Plasmid Carried by Clinical Klebsiella spp.
por: Xiao, Tao, et al.
Publicado: (2022)

Distribution and Spread of the Mobilized RND Efflux Pump Gene Cluster tmexCD-toprJ in Klebsiella pneumoniae from Different Sources
por: Sun, Lin, et al.
Publicado: (2023)

Emergence of Tigecycline and Carbapenem-Resistant Citrobacter freundii Co-Carrying tmexCD1-toprJ1, bla(KPC-2), and bla(NDM-1) from a Sepsis Patient
por: Huang, Jinzhu, et al.
Publicado: (2023)

A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying bla(NDM-4), tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline
por: Hirabayashi, Aki, et al.
Publicado: (2021)

Emergence of Tigecycline and Carbapenem-Resistant Citrobacter freundii Co-Carrying tmexCD1-toprJ1, bla(KPC-2), and bla(NDM-1) from a Sepsis Patient [Corrigendum]
Publicado: (2023)

Emergence of the resistance‐nodulation‐division efflux pump tmexCD3‐toprJ3 gene confers resistance to tigecycline in Pseudomonas juntendi and Proteus terrae isolated from a pig farm in China
por: Yang, Jie, et al.
Publicado: (2022)

Coexistence of tmexCD3-toprJ1b tigecycline resistance genes with two novel bla (VIM-2)-carrying and bla (OXA-10)-carrying transposons in a Pseudomononas asiatica plasmid
por: Li, Qin, et al.
Publicado: (2023)

Emergence of Plasmids Co-Harboring Carbapenem Resistance Genes and tmexCD2-toprJ2 in Sequence Type 11 Carbapenem Resistant Klebsiella pneumoniae Strains
por: Li, Xi, et al.
Publicado: (2022)

Emergence and Inter- and Intrahost Evolution of Pandrug-Resistant Klebsiella pneumoniae Coharboring tmexCD1-toprJ1, bla(NDM-1), and bla(KPC-2)
por: Liu, Chao, et al.
Publicado: (2023)

Occurrence and characterization of plasmids carrying tmexCD1-toprJ1, bla (DHA-1), and bla (CTX-M-127), in clinical Klebsiella pneumoniae strains
por: Qu, Ying, et al.
Publicado: (2023)

Characterization of IncHI1B Plasmids Encoding Efflux Pump TmexCD2-ToprJ2 in Carbapenem-Resistant Klebsiella variicola, Klebsiella quasipneumoniae, and Klebsiella michiganensis Strains
por: Wang, Yujiao, et al.
Publicado: (2021)

Multiple Copies of Mobile Tigecycline Resistance Efflux Pump Gene Cluster tmexC2D2.2-toprJ2 Identified in Chromosome of Aeromonas spp.
por: Wang, Cheng-Zhen, et al.
Publicado: (2022)

Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin Carrying bla(IMP-45), tet(X6), and tmexCD3-toprJ3 on an Inc(pRBL16) Plasmid
por: Dong, Ning, et al.
Publicado: (2022)

Emergence of an ST1326 (CG258) Multi-Drug Resistant Klebsiella pneumoniae Co-harboring mcr-8.2, ESBL Genes, and the Resistance-Nodulation-Division Efflux Pump Gene Cluster tmexCD1-toprJ1 in China
por: Liu, Congcong, et al.
Publicado: (2022)

Emergence of Aeromonas veronii strain co-harboring bla(KPC–2), mcr-3.17, and tmexC3.2-tmexD3.3-toprJ1b cluster from hospital sewage in China
por: Zhu, Zhichen, et al.
Publicado: (2023)

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria
por: Deng, Tian, et al.
Publicado: (2022)

Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
por: Liu, Yuan, et al.
Publicado: (2021)

The Benzydamine Experience: A Systematic Review of Benzydamine Abuse
por: Stefania, Chiappini, et al.
Publicado: (2021)

Effects of benzydamine and mouthwashes containing benzydamine on Candida albicans adhesion, biofilm formation, regrowth, and persistence
por: Ardizzoni, Andrea, et al.
Publicado: (2022)

Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing
por: Liu, Yuan, et al.
Publicado: (2021)

Casein Micelles as Nanocarriers for Benzydamine Delivery
por: Zahariev, Nikolay, et al.
Publicado: (2021)

Resensitizing multidrug-resistant Gram-negative bacteria to carbapenems and colistin using disulfiram
por: Chen, Chen, et al.
Publicado: (2023)

Cysteine Potentiates Bactericidal Antibiotics Activity Against Gram-Negative Bacterial Persisters
por: Liu, Yuan, et al.
Publicado: (2020)

Evaluating the performance characteristics of different antimicrobial susceptibility testing methodologies for testing susceptibility of gram-negative bacteria to tigecycline
por: Babaei, Sima, et al.
Publicado: (2021)

The present and the future of benzydamine: expert opinion paper
por: Bossi, Paolo, et al.
Publicado: (2023)

Safety and effectiveness of tigecycline combination therapy in renal transplant patients with infection due to carbapenem-resistant gram-negative bacteria
por: Wang, Qin, et al.
Publicado: (2023)

A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria
por: Xu, Tianqi, et al.
Publicado: (2023)

Assessment of the Activity of Tigecycline against Gram-Positive and Gram-Negative Organisms Collected from Italy between 2012 and 2014, as Part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.)
por: Stefani, Stefania, et al.
Publicado: (2016)

The tigecycline evaluation and surveillance trial; assessment of the activity of tigecycline and other selected antibiotics against gram-positive and gram-negative pathogens from France collected between 2004 and 2016
por: Decousser, Jean-Winoc, et al.
Publicado: (2018)

Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis
por: Sanghai, Piyush, et al.
Publicado: (2016)

The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis
por: Nicolatou-Galitis, Ourania, et al.
Publicado: (2021)

Casein Microgels as Benzydamine Hydrochloride Carriers for Prolonged Release
por: Milenkova, Sofia, et al.
Publicado: (2022)

topr: an R package for viewing and annotating genetic association results
por: Juliusdottir, Thorhildur
Publicado: (2023)

High dose of tigecycline for extremely resistant Gram-negative pneumonia: yes, we can
por: Garnacho-Montero, José, et al.
Publicado: (2014)

Global Assessment of the Activity of Tigecycline against Multidrug-Resistant Gram-Negative Pathogens between 2004 and 2014 as Part of the Tigecycline Evaluation and Surveillance Trial
por: Giammanco, Anna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sdu1k3urb93orcjulcl2kag4gc