GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice

(1) Background: Growth differentiation factor-15 (GDF-15) is associated with cardiovascular diseases and autophagy in human macrophages (MΦ). Thus, we are interested in investigating autophagic mechanisms with special respect to the role of GDF-15. (2) Methods: Recombinant (r)GDF-15 and siRNA GDF-15...

Descripción completa

Detalles Bibliográficos
Autores principales: Heduschke, Aline, Ackermann, Kathrin, Wilhelm, Beate, Mey, Lilli, Bonaterra, Gabriel Alejandro, Kinscherf, Ralf, Schwarz, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470202/
https://www.ncbi.nlm.nih.gov/pubmed/34571994
http://dx.doi.org/10.3390/cells10092346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470202/
https://www.ncbi.nlm.nih.gov/pubmed/34571994
http://dx.doi.org/10.3390/cells10092346

Ejemplares similares