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GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice

(1) Background: Growth differentiation factor-15 (GDF-15) is associated with cardiovascular diseases and autophagy in human macrophages (MΦ). Thus, we are interested in investigating autophagic mechanisms with special respect to the role of GDF-15. (2) Methods: Recombinant (r)GDF-15 and siRNA GDF-15...

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Detalles Bibliográficos
Autores principales:	Heduschke, Aline, Ackermann, Kathrin, Wilhelm, Beate, Mey, Lilli, Bonaterra, Gabriel Alejandro, Kinscherf, Ralf, Schwarz, Anja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470202/ https://www.ncbi.nlm.nih.gov/pubmed/34571994 http://dx.doi.org/10.3390/cells10092346

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