Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction

Cancer stem cells (CSCs) have high tumor-initiating capacity and are resistant to chemotherapeutic reagents; thus eliminating CSCs is essential to improving the prognosis. Recently, we reported that dexamethasone increases the effects of gemcitabine on pancreatic CSCs; however, the mechanism involve...

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Detalles Bibliográficos
Autores principales: Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Yoshioka, Takashi, Okada, Masashi, Kitanaka, Chifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470402/
https://www.ncbi.nlm.nih.gov/pubmed/34575034
http://dx.doi.org/10.3390/life11090885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470402/
https://www.ncbi.nlm.nih.gov/pubmed/34575034
http://dx.doi.org/10.3390/life11090885

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