Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)

Renal cell carcinoma (RCC) is a malignancy of the kidney originating from the tubular epithelium. Inactivation of the von Hippel–Lindau tumor-suppressor gene (VHL) is found in most clear cell renal cell carcinomas (ccRCCs). The VHL–HIF–VEGF/VEGFR pathway, which involves the von Hippel–Lindau tumor s...

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Detalles Bibliográficos
Autores principales: Kim, Hyunho, Shim, Byoung Yong, Lee, Seung-Ju, Lee, Ji Youl, Lee, Hyo-Jin, Kim, In-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470481/
https://www.ncbi.nlm.nih.gov/pubmed/34575959
http://dx.doi.org/10.3390/ijms22189795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470481/
https://www.ncbi.nlm.nih.gov/pubmed/34575959
http://dx.doi.org/10.3390/ijms22189795

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