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Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)

Renal cell carcinoma (RCC) is a malignancy of the kidney originating from the tubular epithelium. Inactivation of the von Hippel–Lindau tumor-suppressor gene (VHL) is found in most clear cell renal cell carcinomas (ccRCCs). The VHL–HIF–VEGF/VEGFR pathway, which involves the von Hippel–Lindau tumor s...

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Detalles Bibliográficos
Autores principales:	Kim, Hyunho, Shim, Byoung Yong, Lee, Seung-Ju, Lee, Ji Youl, Lee, Hyo-Jin, Kim, In-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470481/ https://www.ncbi.nlm.nih.gov/pubmed/34575959 http://dx.doi.org/10.3390/ijms22189795

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