Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

Dienone compounds with a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore have been widely reported to show tumor cell selectivity. These compounds target the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor cells. The induction of oxidative stress, depletion of glut...

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Detalles Bibliográficos
Autores principales: Selvaraju, Karthik, Lotfi, Kourosh, Gubat, Johannes, Miquel, Maria, Nilsson, Amanda, Hill, Julia, Jensen, Lasse D., Linder, Stig, D’Arcy, Pádraig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470745/
https://www.ncbi.nlm.nih.gov/pubmed/34572552
http://dx.doi.org/10.3390/biom11091339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470745/
https://www.ncbi.nlm.nih.gov/pubmed/34572552
http://dx.doi.org/10.3390/biom11091339

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