Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases

Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450-dependent oxidation via sulfenic acids to the act...

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Detalles Bibliográficos
Autores principales: Kiebist, Jan, Schmidtke, Kai-Uwe, Schramm, Marina, König, Rosalie, Quint, Stephan, Kohlmann, Johannes, Zuhse, Ralf, Ullrich, René, Hofrichter, Martin, Scheibner, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470877/
https://www.ncbi.nlm.nih.gov/pubmed/34575790
http://dx.doi.org/10.3390/jof7090752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470877/
https://www.ncbi.nlm.nih.gov/pubmed/34575790
http://dx.doi.org/10.3390/jof7090752

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