Cargando…
Biocatalytic Syntheses of Antiplatelet Metabolites of the Thienopyridines Clopidogrel and Prasugrel Using Fungal Peroxygenases
Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450-dependent oxidation via sulfenic acids to the act...
Autores principales: | Kiebist, Jan, Schmidtke, Kai-Uwe, Schramm, Marina, König, Rosalie, Quint, Stephan, Kohlmann, Johannes, Zuhse, Ralf, Ullrich, René, Hofrichter, Martin, Scheibner, Katrin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470877/ https://www.ncbi.nlm.nih.gov/pubmed/34575790 http://dx.doi.org/10.3390/jof7090752 |
Ejemplares similares
-
Novel Unspecific Peroxygenase from Truncatella angustata Catalyzes the Synthesis of Bioactive Lipid Mediators
por: König, Rosalie, et al.
Publicado: (2022) -
Cell-Free Protein Synthesis with Fungal Lysates for the Rapid Production of Unspecific Peroxygenases
por: Schramm, Marina, et al.
Publicado: (2022) -
A Peroxygenase from Chaetomium globosum Catalyzes the Selective Oxygenation of Testosterone
por: Kiebist, Jan, et al.
Publicado: (2017) -
Peroxide-Mediated Oxygenation of Organic Compounds by Fungal Peroxygenases
por: Hofrichter, Martin, et al.
Publicado: (2022) -
Fatty Acid Chain Shortening by a Fungal Peroxygenase
por: Olmedo, Andrés, et al.
Publicado: (2017)