Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells

SIMPLE SUMMARY: The EGFR is a tyrosine kinase receptor that responds to different stresses such as UV irradiation, hypoxia and drug treatment by internalizing into endosomal compartments. Receptor trafficking and degradation due to tyrosine kinase inhibitors has been widely studied in two- dimension...

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Detalles Bibliográficos
Autores principales: Betriu, Nausika, Andreeva, Anna, Semino, Carlos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470972/
https://www.ncbi.nlm.nih.gov/pubmed/34572731
http://dx.doi.org/10.3390/cancers13184504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470972/
https://www.ncbi.nlm.nih.gov/pubmed/34572731
http://dx.doi.org/10.3390/cancers13184504

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