Multi-Target Actions of Acridones from Atalantia monophylla towards Alzheimer’s Pathogenesis and Their Pharmacokinetic Properties

Ten acridones isolated from Atalantia monophylla were evaluated for effects on Alzheimer’s disease pathogenesis including antioxidant effects, acetylcholinesterase (AChE) inhibition, prevention of beta-amyloid (Aβ) aggregation and neuroprotection. To understand the mechanism, the type of AChE inhibi...

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Detalles Bibliográficos
Autores principales: Takomthong, Pitchayakarn, Waiwut, Pornthip, Yenjai, Chavi, Sombatsri, Aonnicha, Reubroycharoen, Prasert, Lei, Luo, Lai, Ren, Chaiwiwatrakul, Suchada, Boonyarat, Chantana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470973/
https://www.ncbi.nlm.nih.gov/pubmed/34577588
http://dx.doi.org/10.3390/ph14090888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470973/
https://www.ncbi.nlm.nih.gov/pubmed/34577588
http://dx.doi.org/10.3390/ph14090888

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