Coevolved Multidrug-Resistant HIV-1 Protease and Reverse Transcriptase Influences Integrase Drug Susceptibility and Replication Fitness

Integrase strand transfer inhibitors (InSTIs) are recommended agents in first-line combination antiretroviral therapy (cART). We examined the evolution of drug resistance mutations throughout HIV-1 pol and the effects on InSTI susceptibility and viral fitness. We performed single-genome sequencing o...

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Detalles Bibliográficos
Autores principales: Martin, Supang A., Cane, Patricia A., Pillay, Deenan, Mbisa, Jean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470981/
https://www.ncbi.nlm.nih.gov/pubmed/34578103
http://dx.doi.org/10.3390/pathogens10091070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470981/
https://www.ncbi.nlm.nih.gov/pubmed/34578103
http://dx.doi.org/10.3390/pathogens10091070

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