Cargando…

Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line

Non-alcoholic fatty liver disease (NAFLD) is caused by excess lipid accumulation in hepatocytes. Genome-wide association studies have identified a strong association of NAFLD with non-synonymous E167K amino acid mutation in the transmembrane 6 superfamily member 2 (TM6SF2) protein. The E167K mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pant, Asmita, Chen, Yue, Kuppa, Annapurna, Du, Xiaomeng, Halligan, Brian D., Speliotes, Elizabeth K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471112/ https://www.ncbi.nlm.nih.gov/pubmed/34575933 http://dx.doi.org/10.3390/ijms22189758

Ejemplares similares

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
por: Chen, Vincent L., et al.
Publicado: (2021)

Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids
por: Handelman, Samuel K., et al.
Publicado: (2022)

Author Correction: Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
por: Chen, Vincent L., et al.
Publicado: (2023)

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis
por: Chen, Vincent L., et al.
Publicado: (2019)

Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance
por: Rahim, Nur Syafiqah, et al.
Publicado: (2023)

Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma
por: Chen, Zhouxun, et al.
Publicado: (2011)

TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis
por: Basyte-Bacevice, Viktorija, et al.
Publicado: (2019)

Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics
por: Gatticchi, Leonardo, et al.
Publicado: (2020)

Targeting TM4SF5 with anti-TM4SF5 monoclonal antibody suppresses the growth and motility of human pancreatic cancer cells
por: Park, Sangkyu, et al.
Publicado: (2020)

TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells
por: Huang, Yu-Kun, et al.
Publicado: (2016)

TM4SF5-Mediated Regulation of Hepatocyte Transporters during Metabolic Liver Diseases
por: Kim, Ji Eon, et al.
Publicado: (2022)

Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis
por: Zhu, Wenzhen, et al.
Publicado: (2022)

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
por: Smagris, Eriks, et al.
Publicado: (2016)

Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity
por: Ahn, Hye-Mi, et al.
Publicado: (2017)

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats
por: Luo, Fei, et al.
Publicado: (2021)

Liver-specific deletion of Mttp versus Tm6sf2 reveals distinct defects in stepwise VLDL assembly
por: Newberry, Elizabeth P., et al.
Publicado: (2021)

The Genetics of Clinical Liver Diseases: Insight into the TM6SF2 E167K Variant
por: Zhang, Xiaoyu, et al.
Publicado: (2018)

PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
por: Lisboa, Quelson Coelho, et al.
Publicado: (2020)

TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease
por: Luo, Fei, et al.
Publicado: (2021)

TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes
por: Sun, Hyunseung, et al.
Publicado: (2021)

The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism
por: Chen, Lizhen, et al.
Publicado: (2017)

Risk of Alcohol Abuse in Humans with Attention-deficit/Hyperactivity Disorder Symptoms
por: Kuppa, Annapurna, et al.
Publicado: (2019)

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes
por: Ryu, Jihye, et al.
Publicado: (2017)

Homology modeling and global computational mutagenesis of human myosin VIIa
por: Kuppa, Annapurna, et al.
Publicado: (2021)

TM6SF2 E167K Variant Overexpression Promotes Expression of Inflammatory Cytokines in the HCC Cell Line HEPA 1-6
por: Du, Shuixian, et al.
Publicado: (2019)

Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans
por: Borén, Jan, et al.
Publicado: (2020)

Lipid Droplet-Associated Factors, PNPLA3, TM6SF2, and HSD17B Proteins in Hepatopancreatobiliary Cancer
por: Sunami, Yoshiaki, et al.
Publicado: (2021)

TM4SF5-mediated protein-protein networks and tumorigenic roles
por: Lee, Jung Weon
Publicado: (2014)

The loss of Tm7sf gene accelerates skin papilloma formation in mice
por: Bellezza, I., et al.
Publicado: (2015)

Amino acid transporters as tetraspanin TM4SF5 binding partners
por: Jung, Jae Woo, et al.
Publicado: (2020)

The TM6SF2 variant as a risk factor for hepatocellular carcinoma development in chronic liver disease patients
por: Raia, Gamal Y. S., et al.
Publicado: (2022)

N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application
por: Song, Haeng Eun, et al.
Publicado: (2021)

TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo
por: Cao, Jia, et al.
Publicado: (2015)

TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth
por: Singhal, Megha, et al.
Publicado: (2019)

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
por: Liu, Yang-Lin, et al.
Publicado: (2014)

Disruption of the ERLIN–TM6SF2–APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease
por: Li, Bo-Tao, et al.
Publicado: (2020)

Liver‐originated small extracellular vesicles with TM4SF5 target brown adipose tissue for homeostatic glucose clearance
por: Jung, Jae Woo, et al.
Publicado: (2022)

The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis
por: Wu, Yin-Juan, et al.
Publicado: (2021)

TM6SF2 rs58542926 is related to hepatic steatosis, fibrosis and serum lipids both in adults and children: A meta-analysis
por: Li, Xue-Ying, et al.
Publicado: (2022)

A Novel Role for Tm7sf2 Gene in Regulating TNFα Expression
por: Bellezza, Ilaria, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_skr4hdolgd142l28catqps7pfd