Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival

SIMPLE SUMMARY: DNA methyltransferase-1 (DNMT1) is a key epigenetic regulatory protein of gene expression in cutaneous melanoma. DNMT1 is acetylated by TIP60 promoting its degradation. This study demonstrated that DNMT1 and ac-DNMT1 protein levels were inversely correlated in stage III (n = 17) and...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoqing, Bustos, Matias A., Shoji, Yoshiaki, Ramos, Romela Irene, Iida, Yuuki, Gentry, Rebecca, Takeshima, Teh-Ling, Hoon, Dave S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471314/
https://www.ncbi.nlm.nih.gov/pubmed/34572918
http://dx.doi.org/10.3390/cancers13184691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471314/
https://www.ncbi.nlm.nih.gov/pubmed/34572918
http://dx.doi.org/10.3390/cancers13184691

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