Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands

A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized. Conjugates act simultaneously on several biological structures and processes involved in the pathogenesis...

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Detalles Bibliográficos
Autores principales: Bachurin, Sergey O., Makhaeva, Galina F., Shevtsova, Elena F., Aksinenko, Alexey Yu., Grigoriev, Vladimir V., Shevtsov, Pavel N., Goreva, Tatiana V., Epishina, Tatiana A., Kovaleva, Nadezhda V., Pushkareva, Elena A., Boltneva, Natalia P., Lushchekina, Sofya V., Gabrelyan, Alexey V., Zamoyski, Vladimir L., Dubova, Lyudmila G., Rudakova, Elena V., Fisenko, Vladimir P., Bovina, Elena V., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471380/
https://www.ncbi.nlm.nih.gov/pubmed/34576998
http://dx.doi.org/10.3390/molecules26185527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471380/
https://www.ncbi.nlm.nih.gov/pubmed/34576998
http://dx.doi.org/10.3390/molecules26185527

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