Cargando…
Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line
Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebrates, the presence or absence of oestrogen dictates gonad differentiation, while in mammals, this mechanism has been supplanted by the testis-determining gene SRY. Exogeno...
Autores principales: | Stewart, Melanie K., Bernard, Pascal, Ang, Ching-Seng, Mattiske, Deidre M., Pask, Andrew J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471392/ https://www.ncbi.nlm.nih.gov/pubmed/34576208 http://dx.doi.org/10.3390/ijms221810046 |
Ejemplares similares
-
Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health
por: Stewart, Melanie K., et al.
Publicado: (2020) -
Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line
por: Stewart, Melanie K., et al.
Publicado: (2020) -
Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives
por: Mattiske, Deidre M., et al.
Publicado: (2021) -
Granulosa cell tumor of the testis in a newborn
por: Claros, Oliver Rojas, et al.
Publicado: (2014) -
Prenatal exposure to diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development
por: Rogers, Rachael E, et al.
Publicado: (2023)