Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

The aminoglycoside 6′-N-acetyltransferase type Ib (AAC(6′)-Ib) is a common cause of resistance to amikacin and other aminoglycosides in Gram-negatives. Utilization of mixture-based combinatorial libraries and application of the positional scanning strategy identified an inhibitor of AAC(6′)-Ib. This...

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Detalles Bibliográficos
Autores principales: Rocha, Kenneth, Magallon, Jesus, Reeves, Craig, Phan, Kimberly, Vu, Peter, Oakley-Havens, Crista L., Kwan, Stella, Ramirez, Maria Soledad, LaVoi, Travis, Donow, Haley, Chapagain, Prem, Santos, Radleigh, Pinilla, Clemencia, Giulianotti, Marc A., Tolmasky, Marcelo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471502/
https://www.ncbi.nlm.nih.gov/pubmed/34572404
http://dx.doi.org/10.3390/biomedicines9091218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471502/
https://www.ncbi.nlm.nih.gov/pubmed/34572404
http://dx.doi.org/10.3390/biomedicines9091218

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