Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage

Intracellular metabolism of excess glucose induces mitochondrial dysfunction and diversion of glycolytic intermediates into branch pathways, leading to cell injury and inflammation. Hyperglycemia-driven overproduction of mitochondrial superoxide was thought to be the initiator of these biochemical c...

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Detalles Bibliográficos
Autores principales: Iacobini, Carla, Vitale, Martina, Pugliese, Giuseppe, Menini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471680/
https://www.ncbi.nlm.nih.gov/pubmed/34572324
http://dx.doi.org/10.3390/biomedicines9091139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471680/
https://www.ncbi.nlm.nih.gov/pubmed/34572324
http://dx.doi.org/10.3390/biomedicines9091139

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