CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. NADH is converted into NAD(+) by the enzyme Lactoba...

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Detalles Bibliográficos
Autores principales: Garcia-Canaveras, Juan C., Heo, David, Trefely, Sophie, Leferovich, John, Xu, Chong, Philipson, Benjamin I., Ghassemi, Saba, Milone, Michael C., Moon, Edmund K., Snyder, Nathaniel W., June, Carl H., Rabinowitz, Joshua D., O’Connor, Roddy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472053/
https://www.ncbi.nlm.nih.gov/pubmed/34571983
http://dx.doi.org/10.3390/cells10092334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472053/
https://www.ncbi.nlm.nih.gov/pubmed/34571983
http://dx.doi.org/10.3390/cells10092334

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