Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization

BMI-1, a polycomb ring finger oncogene, is highly expressed in multiple cancer cells and is involved in cancer cell proliferation, invasion, and apoptosis. BMI-1 represents a cancer stemness marker that is associated with the regulation of stem cell self-renewal. In this study, pharmacological inhib...

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Detalles Bibliográficos
Autores principales: Wu, Kaixin, Woo, Seon-Min, Seo, Seung-Un, Kwon, Taeg-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472307/
https://www.ncbi.nlm.nih.gov/pubmed/34576269
http://dx.doi.org/10.3390/ijms221810107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472307/
https://www.ncbi.nlm.nih.gov/pubmed/34576269
http://dx.doi.org/10.3390/ijms221810107

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