RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma

SIMPLE SUMMARY: Two deleterious RAD50 loss-of-function germline mutations were identified from the blood DNA of a cohort of 3289 Henan individuals by next-generation sequencing. These rare loss-of-function RAD50 variants were associated with a substantial increased risk of familial esophageal squamo...

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Detalles Bibliográficos
Autores principales: Ko, Josephine Mun Yee, Lam, Shiu Yeung, Ning, Lvwen, Chai, Annie Wai Yeeng, Lei, Lisa Chan, Choi, Sheyne Sta Ana, Wong, Carissa Wing Yan, Lung, Maria Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472384/
https://www.ncbi.nlm.nih.gov/pubmed/34572942
http://dx.doi.org/10.3390/cancers13184715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472384/
https://www.ncbi.nlm.nih.gov/pubmed/34572942
http://dx.doi.org/10.3390/cancers13184715

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