Cargando…

Glutamine Modulates Expression and Function of Glucose 6-Phosphate Dehydrogenase via NRF2 in Colon Cancer Cells

Nucleotide pools need to be constantly replenished in cancer cells to support cell proliferation. The synthesis of nucleotides requires glutamine and 5-phosphoribosyl-1-pyrophosphate produced from ribose-5-phosphate via the oxidative branch of the pentose phosphate pathway (ox-PPP). Both PPP and glu...

Descripción completa

Detalles Bibliográficos
Autores principales: Polat, Ibrahim H., Tarrado-Castellarnau, Míriam, Benito, Adrian, Hernandez-Carro, Claudia, Centelles, Josep, Marin, Silvia, Cascante, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472416/
https://www.ncbi.nlm.nih.gov/pubmed/34572981
http://dx.doi.org/10.3390/antiox10091349