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Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery

In this work, we propose chitosan (CS)-based nanocapsules (NCs) for pulmonary gene delivery. Hyaluronic acid (HA) was incorporated in the NCs composition (HA/CS NCs) aiming to promote gene transfection in the lung epithelium. NCs were loaded with a model plasmid (pCMV-βGal) to easily evaluate their...

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Detalles Bibliográficos
Autores principales: Fernández-Paz, Estefanía, Feijoo-Siota, Lucía, Gaspar, Maria Manuela, Csaba, Noemi, Remuñán-López, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472419/
https://www.ncbi.nlm.nih.gov/pubmed/34575452
http://dx.doi.org/10.3390/pharmaceutics13091377