Cargando…

HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells

During type 1 diabetes mellitus (T1DM) development, beta-cells undergo intense endoplasmic reticulum (ER) stress that could result in apoptosis through the failure of adaptation to the unfolded protein response (UPR). Islet transplantation is considered an attractive alternative among beta-cell repl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gomes, Vinícius M., Wailemann, Rosangela A. M., Arini, Gabriel S., Oliveira, Talita C., Almeida, Daria R. Q., dos Santos, Ancély F., Terra, Letícia F., Lortz, Stephan, Labriola, Leticia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472426/ https://www.ncbi.nlm.nih.gov/pubmed/34571827 http://dx.doi.org/10.3390/cells10092178

Ejemplares similares

Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
por: dos Santos, Ancély F., et al.
Publicado: (2017)

Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells
por: Dos Santos, Ancély F., et al.
Publicado: (2020)

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells
por: Gomes, Luciana R, et al.
Publicado: (2012)

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes
por: Ke, Lei, et al.
Publicado: (2011)

Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution
por: Benndorf, Rainer, et al.
Publicado: (2022)

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8
por: Shatov, Vladislav M., et al.
Publicado: (2018)

Proteotoxicity and Neurodegenerative Diseases
por: Ruz, Clara, et al.
Publicado: (2020)

Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis
por: Lambelet, Martine, et al.
Publicado: (2018)

Cotransplantation of marginal mass allogeneic islets with 3D culture-derived adult human skin cells improves glycemia in diabetic mice
por: Andreone, L., et al.
Publicado: (2023)

HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins
por: Arrigo, André-Patrick, et al.
Publicado: (2014)

Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells
por: Tan, X., et al.
Publicado: (2017)

Proteasome Activation to Combat Proteotoxicity
por: Jones, Corey L., et al.
Publicado: (2019)

Aneuploidy and proteotoxic stress in cancer
por: Donnelly, Neysan, et al.
Publicado: (2015)

Editorial: Targeting Cardiac Proteotoxicity
por: Ranek, Mark J., et al.
Publicado: (2021)

Characterization of Hspb8 in Zebrafish
por: Dubińska-Magiera, Magda, et al.
Publicado: (2020)

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes
por: Raimundo, Ana F., et al.
Publicado: (2022)

HSPB1 Facilitates the Formation of Non-Centrosomal Microtubules
por: Almeida-Souza, Leonardo, et al.
Publicado: (2013)

Vitamin B(12) impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle
por: Lam, Andy B., et al.
Publicado: (2021)

Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3
por: Clark, Alice R., et al.
Publicado: (2018)

Enhancing proteotoxic stress as an anticancer strategy
por: Grant, Steven
Publicado: (2011)

Proteotoxic stress targeted therapy (PSTT)
por: Sherman, Michael Y.
Publicado: (2011)

Glucose delays age-dependent proteotoxicity
por: Tauffenberger, Arnaud, et al.
Publicado: (2012)

Proteostasis and Proteotoxicity in the Network Medicine Era
por: Lualdi, Marta, et al.
Publicado: (2020)

Coordination between aminoacylation and editing to protect against proteotoxicity
por: Zhang, Hong, et al.
Publicado: (2023)

Phosphoserine-86-HSPB1 (pS86-HSPB1) is cytoplasmic and highly induced in rat myometrium at labour
por: Miskiewicz, E. I., et al.
Publicado: (2022)

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis
por: Chou, Shiuh-Dih, et al.
Publicado: (2012)

Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners
por: Hussein, Rasha M., et al.
Publicado: (2015)

Bmal1 Regulates the Redox Rhythm of HSPB1, and Homooxidized HSPB1 Attenuates the Oxidative Stress Injury of Cardiomyocytes
por: Liu, Xiehong, et al.
Publicado: (2021)

Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression
por: Gianniou, Despoina D., et al.
Publicado: (2023)

Proteotoxic stress is a driver of the loser status and of cell competition
por: Baumgartner, Michael E., et al.
Publicado: (2021)

Clusterin protects neurons against intracellular proteotoxicity
por: Gregory, Jenna M., et al.
Publicado: (2017)

Proteotoxic Stress and Cell Death in Cancer Cells
por: Brancolini, Claudio, et al.
Publicado: (2020)

The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias
por: Lee, Davin, et al.
Publicado: (2020)

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases
por: McAlary, Luke, et al.
Publicado: (2019)

Mitochondrial metabolism promotes adaptation to proteotoxic stress
por: Tsvetkov, Peter, et al.
Publicado: (2019)

Transcriptional lockdown during acute proteotoxic stress
por: Sawarkar, Ritwick
Publicado: (2022)

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome
por: Grose, Julianne H., et al.
Publicado: (2015)

Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells
por: Castillo, Lilian Fedra, et al.
Publicado: (2016)

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11
por: Shields, Jeremiah N., et al.
Publicado: (2019)

Mutant HSPB8 causes motor neuron-specific neurite degeneration
por: Irobi, Joy, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_0nol2oiv1idh7tq7heflpjqa72