Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis

Objective: to identify new single-nucleotide polymorphisms (SNPs) in genes encoding proteins involved in methotrexate (MTX) metabolism and to evaluate the associations of these SNPs with MTX toxicity or intolerance in a southern Spanish cohort of patients with rheumatoid arthritis (RA). Methods: An...

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Detalles Bibliográficos
Autores principales: Escudero-Contreras, Alejandro, López-Medina, Clementina, Collantes-Estévez, Eduardo, Ortega-Castro, Rafaela, Calvo-Gutiérrez, Jerusalem, Mena-Vázquez, Natalia, Panero-Lamothe, Blanca, Manzanares-Martín, Bárbara, Cáliz-Cáliz, Rafael, Jiménez-Morales, Alberto, Ruiz-Jiménez, Mayte, Font-Ugalde, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472669/
https://www.ncbi.nlm.nih.gov/pubmed/34575187
http://dx.doi.org/10.3390/jcm10184070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472669/
https://www.ncbi.nlm.nih.gov/pubmed/34575187
http://dx.doi.org/10.3390/jcm10184070

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