Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine

We attempted to design irbesartan nanocrystalline (IRB-NC) suspensions by the bead mill method, and we evaluated the bioavailability (BA) in the oral administration of the nanocrystalline drug. The mean particle size of the IRB-NC suspensions was approximately 140 nm, and the crystalline structure o...

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Detalles Bibliográficos
Autores principales: Deguchi, Saori, Ogata, Fumihiko, Watanabe, Masaki, Otake, Hiroko, Yamamoto, Naoki, Kawasaki, Naohito, Nagai, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472685/
https://www.ncbi.nlm.nih.gov/pubmed/34575479
http://dx.doi.org/10.3390/pharmaceutics13091404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472685/
https://www.ncbi.nlm.nih.gov/pubmed/34575479
http://dx.doi.org/10.3390/pharmaceutics13091404

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