ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism

The cytosolic enzyme ethylmalonyl-CoA decarboxylase (ECHDC1) decarboxylates ethyl- or methyl-malonyl-CoA, two side products of acetyl-CoA carboxylase. These CoA derivatives can be used to synthesize a subset of branched-chain fatty acids (FAs). We previously found that ECHDC1 limits the synthesis of...

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Detalles Bibliográficos
Autores principales: Dewulf, Joseph P., Paquay, Stéphanie, Marbaix, Etienne, Achouri, Younès, Van Schaftingen, Emile, Bommer, Guido T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473548/
https://www.ncbi.nlm.nih.gov/pubmed/34419447
http://dx.doi.org/10.1016/j.jbc.2021.101083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473548/
https://www.ncbi.nlm.nih.gov/pubmed/34419447
http://dx.doi.org/10.1016/j.jbc.2021.101083

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