Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase

Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we present a 2.7 Å resolution X-ray structure of wild-type IslA fr...

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Detalles Bibliográficos
Autores principales: Dawson, Christopher D., Irwin, Stephania M., Backman, Lindsey R.F., Le, Chip, Wang, Jennifer X., Vennelakanti, Vyshnavi, Yang, Zhongyue, Kulik, Heather J., Drennan, Catherine L., Balskus, Emily P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473560/
https://www.ncbi.nlm.nih.gov/pubmed/33773110
http://dx.doi.org/10.1016/j.chembiol.2021.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473560/
https://www.ncbi.nlm.nih.gov/pubmed/33773110
http://dx.doi.org/10.1016/j.chembiol.2021.03.001

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