Cargando…

Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase

Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we present a 2.7 Å resolution X-ray structure of wild-type IslA fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dawson, Christopher D., Irwin, Stephania M., Backman, Lindsey R.F., Le, Chip, Wang, Jennifer X., Vennelakanti, Vyshnavi, Yang, Zhongyue, Kulik, Heather J., Drennan, Catherine L., Balskus, Emily P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473560/ https://www.ncbi.nlm.nih.gov/pubmed/33773110 http://dx.doi.org/10.1016/j.chembiol.2021.03.001

Ejemplares similares

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
por: Backman, Lindsey RF, et al.
Publicado: (2020)

Mechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme Suggest Reaction Initiation via Hydrogen Atom Transfer
por: Fu, Beverly, et al.
Publicado: (2022)

Multi-Fold Computational Analysis to Discover Novel Putative Inhibitors of Isethionate Sulfite-Lyase (Isla) from Bilophila wadsworthia: Combating Colorectal Cancer and Inflammatory Bowel Diseases
por: Waqas, Muhammad, et al.
Publicado: (2023)

A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia
por: Peck, Spencer C., et al.
Publicado: (2019)

When are two hydrogen bonds better than one? Accurate first-principles models explain the balance of hydrogen bond donors and acceptors found in proteins
por: Vennelakanti, Vyshnavi, et al.
Publicado: (2020)

Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein
por: Andorfer, Mary C., et al.
Publicado: (2021)

The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis
por: Al-Horani, Rami A., et al.
Publicado: (2019)

THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE, GLYCYL LEUCINE, GLYCYL ALANINE, GLYCYL ASPARAGINE, GLYCYL ASPARTIC ACID, AND BIURET BASE BY EREPSIN
por: Northrop, John H., et al.
Publicado: (1928)

In Vitro Activity of Pentamidine Isethionate against Trophozoite and Cyst of Acanthamoeba
por: Behnia, Massoud, et al.
Publicado: (2021)

Randomized Single-Blinded Non-inferiority Trial Of 7 mg/kg Pentamidine Isethionate Versus 4 mg/kg Pentamidine Isethionate for Cutaneous Leishmaniaisis in Suriname
por: Hu, Ricardo V. P. F., et al.
Publicado: (2015)

Isethionate is an intermediate in the degradation of sulfoacetate by the human gut pathobiont Bilophila wadsworthia
por: Liu, Xumei, et al.
Publicado: (2023)

Activation of Glycyl Radical Enzymes—Multiscale Modeling Insights into Catalysis and Radical Control in a Pyruvate Formate-Lyase-Activating Enzyme
por: Hanževački, Marko, et al.
Publicado: (2022)

Structural basis of interprotein electron transfer in bacterial sulfite oxidation
por: McGrath, Aaron P, et al.
Publicado: (2015)

Safety of intrastromal injection of polyhexamethylene biguanide and propamidine isethionate in a rabbit model
por: Lim, Chen-Chee, et al.
Publicado: (2019)

Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity
por: Huang, Yolanda Y., et al.
Publicado: (2018)

Clinical efficacy and mechanism of Pralatrexate combined with Palbociclib Isethionate in treatment of bladder cancer patients
por: Wang, Xiaobin, et al.
Publicado: (2019)

Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium Bilophila wadsworthia
por: Burrichter, Anna G., et al.
Publicado: (2021)

Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters
por: Ávila-Blanco, Manuel Enrique, et al.
Publicado: (2023)

The glycyl-radical enzyme 2-ketobutyrate formate-lyase, TdcE, interacts specifically with the formate-translocating FNT-channel protein FocA
por: Falke, Dörte, et al.
Publicado: (2016)

Tubulin glycylation controls primary cilia length
por: Gadadhar, Sudarshan, et al.
Publicado: (2017)

Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase
por: Yu, Zhaoli, et al.
Publicado: (2023)

Sulfite oxidase deficiency
por: Hundallah, Khalid, et al.
Publicado: (2016)

Free-radical chemistry of sulfite.
por: Neta, P, et al.
Publicado: (1985)

Sulfite Oxidation in Chlorobaculum Tepidum
por: Rodriguez, Jesse, et al.
Publicado: (2011)

Cadmium sulfite hexahydrate revisited
por: Baggio, Sergio, et al.
Publicado: (2008)

Flotation using sodium dodecyl sulphate and sodium lauroyl isethionate for rapid dewatering of Mg(OH)(2) radwaste suspensions
por: Lockwood, Alexander P. G., et al.
Publicado: (2021)

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
por: Valencia-Sánchez, Marco Igor, et al.
Publicado: (2016)

Overexpression of a Maize Sulfite Oxidase Gene in Tobacco Enhances Tolerance to Sulfite Stress via Sulfite Oxidation and CAT-Mediated H(2)O(2) Scavenging
por: Xia, Zongliang, et al.
Publicado: (2012)

New Insights into the Cystine-Sulfite Reaction
por: Zecchini, Matteo, et al.
Publicado: (2019)

Kinetic investigations of sulfite addition to flavanols
por: Bonaldo, Federico, et al.
Publicado: (2020)

Electrocatalytic sulfite biosensor with human sulfite oxidase co-immobilized with cytochrome c in a polyelectrolyte-containing multilayer
por: Spricigo, Roberto, et al.
Publicado: (2008)

(Bi)sulfite Oxidation by Copper,Zinc-Superoxide Dismutase: Sulfite-Derived, Radical-Initiated Protein Radical Formation
por: Ranguelova, Kalina, et al.
Publicado: (2010)

The effect of desulfurization on the postharvest quality and sulfite metabolism in pulp of sulfitated “Feizixiao” Litchi (Litchi chinensis Sonn.) fruits
por: Luo, Tao, et al.
Publicado: (2019)

Biofunctionalisation of Polypyrrole Nanowires Array with Sulfite Oxidase Coupled with the Integration of Platinum Nanoparticles for Ultrasensitive Amperometric Detection of Sulfite
por: Hussain, Shahid, et al.
Publicado: (2023)

Sulfite preservatives effects on the mouth microbiome: Changes in viability, diversity and composition of microbiota
por: Irwin, Sally V., et al.
Publicado: (2022)

Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons
por: Boczonadi, Veronika, et al.
Publicado: (2018)

Glycyl Radical Enzyme-Associated Microcompartments: Redox-Replete Bacterial Organelles
por: Ferlez, Bryan, et al.
Publicado: (2019)

Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease
por: Turkez, Hasan, et al.
Publicado: (2021)

Sulfites inhibit the growth of four species of beneficial gut bacteria at concentrations regarded as safe for food
por: Irwin, Sally V., et al.
Publicado: (2017)

How are “Atypical” Sulfite Dehydrogenases Linked to Cell Metabolism? Interactions between the SorT Sulfite Dehydrogenase and Small Redox Proteins
por: Low, Louie, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_m2vn4sfifbq1s1ej40nj4mshtv