Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

BACKGROUND: The mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly. Cancer cells are characterized by a shift in cellular metabolism from mitochondrial respiration to glycolysis. PDC activit...

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Detalles Bibliográficos
Autores principales: Kuo, Yu-Hsuan, Chan, Ti-Chun, Lai, Hong-Yue, Chen, Tzu-Ju, Wu, Li-Ching, Hsing, Chung-Hsi, Li, Chien-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473833/
https://www.ncbi.nlm.nih.gov/pubmed/34589439
http://dx.doi.org/10.3389/fonc.2021.749142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473833/
https://www.ncbi.nlm.nih.gov/pubmed/34589439
http://dx.doi.org/10.3389/fonc.2021.749142

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