Cargando…

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

BACKGROUND: The mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly. Cancer cells are characterized by a shift in cellular metabolism from mitochondrial respiration to glycolysis. PDC activit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuo, Yu-Hsuan, Chan, Ti-Chun, Lai, Hong-Yue, Chen, Tzu-Ju, Wu, Li-Ching, Hsing, Chung-Hsi, Li, Chien-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473833/ https://www.ncbi.nlm.nih.gov/pubmed/34589439 http://dx.doi.org/10.3389/fonc.2021.749142

Ejemplares similares

Upregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma
por: Kuo, Yu-Hsuan, et al.
Publicado: (2022)

Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma
por: Liang, Peir-In, et al.
Publicado: (2023)

Overexpression of Dehydrogenase/Reductase 9 Predicts Poor Response to Concurrent Chemoradiotherapy and Poor Prognosis in Rectal Cancer Patients
por: Chen, Tzu-Ju, et al.
Publicado: (2022)

Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis
por: Liao, Kuang-Ming, et al.
Publicado: (2016)

Role of Microtubule-Associated Protein 1b in Urothelial Carcinoma: Overexpression Predicts Poor Prognosis
por: Chien, Tsu-Ming, et al.
Publicado: (2020)

SERPINE2 Overexpression Is Associated with Poor Prognosis of Urothelial Carcinoma
por: Chuang, Hao-Wen, et al.
Publicado: (2021)

Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome
por: Mohammad, Goran Hamid, et al.
Publicado: (2016)

High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract
por: Wang, Chieh-Tien, et al.
Publicado: (2016)

Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract
por: Lee, Hsiang-Ying, et al.
Publicado: (2017)

High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis
por: Lai, Hong-Yue, et al.
Publicado: (2022)

Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder
por: Lee, Yi-Ying, et al.
Publicado: (2016)

SPOCK1 Overexpression Confers a Poor Prognosis in Urothelial Carcinoma
por: Ma, Li-Jung, et al.
Publicado: (2016)

MCM10 overexpression implicates adverse prognosis in urothelial carcinoma
por: Li, Wei-Ming, et al.
Publicado: (2016)

CSF2 Overexpression Is Associated with STAT5 Phosphorylation and Poor Prognosis in Patients with Urothelial Carcinoma
por: Lee, Yi-Ying, et al.
Publicado: (2016)

CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas
por: Hsu, Wei-Chi, et al.
Publicado: (2019)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
por: Zhou, Haiping, et al.
Publicado: (2016)

Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder
por: He, Hong-Lin, et al.
Publicado: (2023)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies
por: Wu, Jiayuan, et al.
Publicado: (2016)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Angiogenesis Driven by the CEBPD–hsa-miR-429–VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression
por: Chan, Ti-Chun, et al.
Publicado: (2022)

Necdin Overexpression Predicts Poor Prognosis in Patients with Urothelial Carcinomas of the Upper Urinary Tract and Urinary Bladder
por: Chang, I-Wei, et al.
Publicado: (2016)

DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study
por: Tsai, Meng-Chen, et al.
Publicado: (2016)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder
por: Liu, Jian-Ye, et al.
Publicado: (2013)

Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions
por: Sradhanjali, Swatishree, et al.
Publicado: (2017)

CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis
por: Wang, Yu-Hui, et al.
Publicado: (2015)

Glutamate Decarboxylase 1 Overexpression as a Poor Prognostic Factor in Patients with Nasopharyngeal Carcinoma
por: Lee, Yi-Ying, et al.
Publicado: (2016)

Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma
por: Wang, Guiping, et al.
Publicado: (2020)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bh6gfd65r2da3vro0vvo715mqj