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Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

BACKGROUND: The mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly. Cancer cells are characterized by a shift in cellular metabolism from mitochondrial respiration to glycolysis. PDC activit...

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Detalles Bibliográficos
Autores principales:	Kuo, Yu-Hsuan, Chan, Ti-Chun, Lai, Hong-Yue, Chen, Tzu-Ju, Wu, Li-Ching, Hsing, Chung-Hsi, Li, Chien-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473833/ https://www.ncbi.nlm.nih.gov/pubmed/34589439 http://dx.doi.org/10.3389/fonc.2021.749142

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