Four and a Half LIM Domains Protein 2 Mediates Bortezomib-Induced Osteogenic Differentiation of Mesenchymal Stem Cells in Multiple Myeloma Through p53 Signaling and β-Catenin Nuclear Enrichment

Myeloma bone disease (MBD), caused by the inhibition of osteoblast activity and the activation of osteoclast in the bone marrow environment, is the most frequent and life-threatening complication in multiple myeloma (MM) patients. Bortezomib (Bzb) was shown to promote MM-derived mesenchymal stem cel...

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Detalles Bibliográficos
Autores principales: Xie, Zhenqing, Xu, Yan, Wei, Xiaojing, An, Gang, Hao, Mu, Yu, Zhen, Qiu, Lugui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473907/
https://www.ncbi.nlm.nih.gov/pubmed/34589431
http://dx.doi.org/10.3389/fonc.2021.729799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473907/
https://www.ncbi.nlm.nih.gov/pubmed/34589431
http://dx.doi.org/10.3389/fonc.2021.729799

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