PDE9A deficiency does not prevent chronic‐hypoxic pulmonary hypertension in mice

Inhibition of cyclic guanosine monophosphate (cGMP)‐specific phosphodiesterases (PDEs) is a cornerstone of pulmonary arterial hypertension (PAH)‐specific therapy. PDE9A, expressed in the heart and lung tissue, has the highest affinity for cGMP of all known PDEs. PDE9A deficiency protects mice agains...

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Detalles Bibliográficos
Autores principales: Kolb, Todd M., Johnston, Laura, Damarla, Mahendra, Kass, David A., Hassoun, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474007/
https://www.ncbi.nlm.nih.gov/pubmed/34569183
http://dx.doi.org/10.14814/phy2.15057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474007/
https://www.ncbi.nlm.nih.gov/pubmed/34569183
http://dx.doi.org/10.14814/phy2.15057

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