Cargando…

PDE9A deficiency does not prevent chronic‐hypoxic pulmonary hypertension in mice

Inhibition of cyclic guanosine monophosphate (cGMP)‐specific phosphodiesterases (PDEs) is a cornerstone of pulmonary arterial hypertension (PAH)‐specific therapy. PDE9A, expressed in the heart and lung tissue, has the highest affinity for cGMP of all known PDEs. PDE9A deficiency protects mice agains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolb, Todd M., Johnston, Laura, Damarla, Mahendra, Kass, David A., Hassoun, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474007/ https://www.ncbi.nlm.nih.gov/pubmed/34569183 http://dx.doi.org/10.14814/phy2.15057

Ejemplares similares

SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model
por: Peloquin, Grace L., et al.
Publicado: (2019)

XOR inhibition with febuxostat accelerates pulmonary endothelial barrier recovery and improves survival in lipopolysaccharide‐induced murine sepsis
por: Damarla, Mahendra, et al.
Publicado: (2017)

Cyclin-Dependent Kinase Five Mediates Activation of Lung Xanthine Oxidoreductase in Response to Hypoxia
por: Kim, Bo S., et al.
Publicado: (2015)

Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems
por: Sivakumar, Dakshinamurthy, et al.
Publicado: (2021)

The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice
por: Stephens, R Scott, et al.
Publicado: (2015)

Preventive but nontherapeutic effect of danshensu on hypoxic pulmonary hypertension
por: Liu, Guang, et al.
Publicado: (2020)

Ventricular mass discriminates pulmonary arterial hypertension as redefined at the Sixth World Symposium on Pulmonary Hypertension
por: Simpson, Catherine E., et al.
Publicado: (2022)

PDE5 inhibitor protects the mitochondrial function of hypoxic myocardial cells
por: Jia, Haiyan, et al.
Publicado: (2019)

Hypoxic pulmonary hypertension: the paradigm is changing
por: Rowan, S C, et al.
Publicado: (2014)

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension
por: Flores, Karen, et al.
Publicado: (2022)

Multi‐Beat Right Ventricular‐Arterial Coupling Predicts Clinical Worsening in Pulmonary Arterial Hypertension
por: Hsu, Steven, et al.
Publicado: (2020)

Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
por: Alexander, M S, et al.
Publicado: (2016)

Upregulation of Aquaporin 1 Mediates Increased Migration and Proliferation in Pulmonary Vascular Cells From the Rat SU5416/Hypoxia Model of Pulmonary Hypertension
por: Yun, Xin, et al.
Publicado: (2021)

β(2)-Adrenergic Receptor-Dependent Attenuation of Hypoxic Pulmonary Vasoconstriction Prevents Progression of Pulmonary Arterial Hypertension in Intermittent Hypoxic Rats
por: Nagai, Hisashi, et al.
Publicado: (2014)

Mitochondrial transplantation attenuates hypoxic pulmonary hypertension
por: Zhu, Liping, et al.
Publicado: (2016)

DNA-PKcs participated in hypoxic pulmonary hypertension
por: Liu, Ying-ying, et al.
Publicado: (2022)

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension
por: Ye, Yi, et al.
Publicado: (2023)

Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle—Implications for hypoxic pulmonary hypertension
por: Hinton, Martha, et al.
Publicado: (2023)

Severity of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension in African Americans
por: Blanco, Isabel, et al.
Publicado: (2014)

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b(rd10) Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2018)

Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary arterial hypertension associated with connective tissue diseases
por: Boueiz, Adel, et al.
Publicado: (2014)

A novel approach to perioperative risk assessment for patients with pulmonary hypertension
por: Hassan, Hussein J., et al.
Publicado: (2021)

Serum uric acid as a marker of disease risk, severity, and survival in systemic sclerosis-related pulmonary arterial hypertension
por: Simpson, Catherine E., et al.
Publicado: (2019)

Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats
por: Hung, Ming Wai, et al.
Publicado: (2017)

Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets
por: Geng, Yumei, et al.
Publicado: (2023)

Supplementation with Tex261 provides a possible preventive treatment for hypoxic pulmonary artery hypertension
por: Chen, Shaokun, et al.
Publicado: (2022)

Spatial and temporal resolution of metabolic dysregulation in the Sugen hypoxia model of pulmonary hypertension
por: Simpson, Catherine E., et al.
Publicado: (2023)

PDE1 or PDE5 inhibition augments NO‐dependent hypoxic constriction of porcine coronary artery via elevating inosine 3′,5′‐cyclic monophosphate level
por: Nan, Yan, et al.
Publicado: (2020)

Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9
por: Ceddia, Ryan P., et al.
Publicado: (2021)

Biopterin Metabolism and eNOS Expression during Hypoxic Pulmonary Hypertension in Mice
por: Dubois, Mathilde, et al.
Publicado: (2013)

Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension
por: Mao, Min, et al.
Publicado: (2018)

Systemic Sclerosis-Associated Pulmonary Hypertension: Spectrum and Impact
por: Naranjo, Mario, et al.
Publicado: (2021)

Poor survival in patients with scleroderma and pulmonary hypertension due to heart failure with preserved ejection fraction
por: Bourji, Khalil I., et al.
Publicado: (2017)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

Hypoxic Pulmonary Vasoconstriction and the Diffusing Capacity in Pulmonary Hypertension Secondary to Idiopathic Pulmonary Fibrosis
por: Sakao, Seiichiro, et al.
Publicado: (2019)

Promises and Pitfalls of Multiomics Approaches to Pulmonary Arterial Hypertension
por: Simpson, Catherine E., et al.
Publicado: (2022)

A narrative review of research advances in hypoxic pulmonary hypertension
por: Chai, Tianci, et al.
Publicado: (2022)

Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension
por: Hannemann, Juliane, et al.
Publicado: (2021)

The Impact of Breathing Hypoxic Gas and Oxygen on Pulmonary Hemodynamics in Patients With Pulmonary Hypertension
por: Carta, Arcangelo F., et al.
Publicado: (2022)

Phenotyping pulmonary hypertension in systemic sclerosis: a moving target
por: Mercurio, Valentina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_msvg10pitf59lahu80vj376qbc