An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

We present a Chemistry and Structure Screen Integrated Efficiently (CASSIE) approach (named for Greek prophet Cassandra) to design inhibitors for cancer biology and pathogenesis. CASSIE provides an effective path to target master keys to control the repair-replication interface for cancer cells and...

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Detalles Bibliográficos
Autores principales: Moiani, Davide, Link, Todd M., Brosey, Chris A., Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E., Tsutakawa, Susan E., Tainer, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474023/
https://www.ncbi.nlm.nih.gov/pubmed/34776222
http://dx.doi.org/10.1016/bs.mie.2021.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474023/
https://www.ncbi.nlm.nih.gov/pubmed/34776222
http://dx.doi.org/10.1016/bs.mie.2021.09.003

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