Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity

[Image: see text] Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, molecular modeling, and biological evaluation of novel HO-1 inhibitors. Specifically, an amide linker in the central spacer and an i...

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Detalles Bibliográficos
Autores principales: Fallica, Antonino N., Sorrenti, Valeria, D’Amico, Agata G., Salerno, Loredana, Romeo, Giuseppe, Intagliata, Sebastiano, Consoli, Valeria, Floresta, Giuseppe, Rescifina, Antonio, D’Agata, Velia, Vanella, Luca, Pittalà, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474116/
https://www.ncbi.nlm.nih.gov/pubmed/34472337
http://dx.doi.org/10.1021/acs.jmedchem.1c00633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474116/
https://www.ncbi.nlm.nih.gov/pubmed/34472337
http://dx.doi.org/10.1021/acs.jmedchem.1c00633

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