Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

[Image: see text] Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA) from degradation, thus increasin...

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Detalles Bibliográficos
Autores principales: Di Fruscia, Paolo, Carbone, Anna, Bottegoni, Giovanni, Berti, Francesco, Giacomina, Francesca, Ponzano, Stefano, Pagliuca, Chiara, Fiasella, Annalisa, Pizzirani, Daniela, Ortega, Jose Antonio, Nuzzi, Andrea, Tarozzo, Glauco, Mengatto, Luisa, Giampà, Roberta, Penna, Ilaria, Russo, Debora, Romeo, Elisa, Summa, Maria, Bertorelli, Rosalia, Armirotti, Andrea, Bertozzi, Sine Mandrup, Reggiani, Angelo, Bandiera, Tiziano, Bertozzi, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474119/
https://www.ncbi.nlm.nih.gov/pubmed/34469137
http://dx.doi.org/10.1021/acs.jmedchem.1c00575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474119/
https://www.ncbi.nlm.nih.gov/pubmed/34469137
http://dx.doi.org/10.1021/acs.jmedchem.1c00575

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