Severe Immune Checkpoint Inhibitor Hepatitis in KRAS G12C-Mutant NSCLC Potentially Triggered by Sotorasib: Case Report

Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening hepatitis in a patient with NSCLC shortly after comm...

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Detalles Bibliográficos
Autores principales: Begum, Parvin, Goldin, Robert D., Possamai, Lucia A., Popat, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474489/
https://www.ncbi.nlm.nih.gov/pubmed/34590053
http://dx.doi.org/10.1016/j.jtocrr.2021.100213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474489/
https://www.ncbi.nlm.nih.gov/pubmed/34590053
http://dx.doi.org/10.1016/j.jtocrr.2021.100213

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