Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice

BACKGROUND: Substantial data have implicated microglial-driven neuroinflammation in Parkinson’s disease (PD) and environmental toxicants have been long expected as triggers of such inflammatory processes. Of course, these environmental insults act in the context of genetic vulnerability factors and...

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Detalles Bibliográficos
Autores principales: Dwyer, Zach, Rudyk, Chris, Situt, Divya, Beauchamp, Sheryl, Abdali, Jawaria, Dinesh, Anu, Legancher, Nathalie, Sun, Hongyu, Schlossmacher, Michael, Hayley, Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474533/
https://www.ncbi.nlm.nih.gov/pubmed/34589856
http://dx.doi.org/10.1016/j.bbih.2020.100079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474533/
https://www.ncbi.nlm.nih.gov/pubmed/34589856
http://dx.doi.org/10.1016/j.bbih.2020.100079

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