Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial

BACKGROUND: Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration of tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients. RESEARCH QUESTION: Does tPA improv...

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Detalles Bibliográficos
Autores principales: Barrett, Christopher D., Moore, Hunter B., Moore, Ernest E., Wang, Janice, Hajizadeh, Negin, Biffl, Walter L., Lottenberg, Lawrence, Patel, Purvesh R., Truitt, Michael S., McIntyre, Robert C., Bull, Todd M., Ammons, Lee Anne, Ghasabyan, Arsen, Chandler, James, Douglas, Ivor S., Schmidt, Eric P., Moore, Peter K., Wright, Franklin L., Ramdeo, Ramona, Borrego, Robert, Rueda, Mario, Dhupa, Achal, McCaul, D. Scott, Dandan, Tala, Sarkar, Pralay K., Khan, Benazir, Sreevidya, Coimbatore, McDaniel, Conner, Grossman Verner, Heather M., Pearcy, Christopher, Anez-Bustillos, Lorenzo, Baedorf-Kassis, Elias N., Jhunjhunwala, Rashi, Shaefi, Shahzad, Capers, Krystal, Banner-Goodspeed, Valerie, Talmor, Daniel S., Sauaia, Angela, Yaffe, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Chest Physicians. Published by Elsevier Inc. 2022
Materias:
Critical Care: Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474873/
https://www.ncbi.nlm.nih.gov/pubmed/34592318
http://dx.doi.org/10.1016/j.chest.2021.09.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474873/
https://www.ncbi.nlm.nih.gov/pubmed/34592318
http://dx.doi.org/10.1016/j.chest.2021.09.024

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