Cargando…

Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial

BACKGROUND: Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration of tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients. RESEARCH QUESTION: Does tPA improv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barrett, Christopher D., Moore, Hunter B., Moore, Ernest E., Wang, Janice, Hajizadeh, Negin, Biffl, Walter L., Lottenberg, Lawrence, Patel, Purvesh R., Truitt, Michael S., McIntyre, Robert C., Bull, Todd M., Ammons, Lee Anne, Ghasabyan, Arsen, Chandler, James, Douglas, Ivor S., Schmidt, Eric P., Moore, Peter K., Wright, Franklin L., Ramdeo, Ramona, Borrego, Robert, Rueda, Mario, Dhupa, Achal, McCaul, D. Scott, Dandan, Tala, Sarkar, Pralay K., Khan, Benazir, Sreevidya, Coimbatore, McDaniel, Conner, Grossman Verner, Heather M., Pearcy, Christopher, Anez-Bustillos, Lorenzo, Baedorf-Kassis, Elias N., Jhunjhunwala, Rashi, Shaefi, Shahzad, Capers, Krystal, Banner-Goodspeed, Valerie, Talmor, Daniel S., Sauaia, Angela, Yaffe, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American College of Chest Physicians. Published by Elsevier Inc. 2022
Materias:	Critical Care: Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474873/ https://www.ncbi.nlm.nih.gov/pubmed/34592318 http://dx.doi.org/10.1016/j.chest.2021.09.024

Ejemplares similares

MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID‐19 severe respiratory failure (MUST COVID): A retrospective cohort study
por: Barrett, Christopher D., et al.
Publicado: (2022)

The Vanguard
Publicado: (1888)

Wailin' at the Vanguard
por: Taylor, Art
Publicado: (1993)

Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial
por: Moore, Hunter B., et al.
Publicado: (2020)

Vanguard management: redesigning the corporate future
por: O'Toole, James
Publicado: (1985)

Vanguard revolutionaries in Latin America : Peru, Colombia, Mexico
por: Rochlin, James Francis, 1956-
Publicado: (2003)

Anesthetics to Prevent Lung Injury in Cardiac Surgery (APLICS): a protocol for a randomized controlled trial
por: O’Gara, Brian, et al.
Publicado: (2019)

Clinical application of esophageal manometry: how I do it
por: Baedorf Kassis, Elias, et al.
Publicado: (2021)

Case reports at the vanguard of 21(st) century medicine
por: Kidd, Michael R, et al.
Publicado: (2012)

Reflections on African Americans in Baseball: No Longer the Vanguard of Change
por: Ruck, Rob
Publicado: (2021)

Fibrinolytic therapy for refractory COVID‐19 acute respiratory distress syndrome: Scientific rationale and review
por: Barrett, Christopher D., et al.
Publicado: (2020)

BSAC Vanguard Series: Why culture matters to tackle antibiotic resistance
por: Charani, Esmita
Publicado: (2022)

At the vanguard: Leaders’ perspectives on establishing healthcare system infection prevention programs
por: Stevens, Michael P., et al.
Publicado: (2022)

Prevention of Early Postoperative Decline (PEaPoD): protocol for a randomized, controlled feasibility trial
por: O’Gara, Brian, et al.
Publicado: (2018)

The Cochrane Skin Group: a vanguard for developing and promoting evidence‐based dermatology
por: Reddi, Anand, et al.
Publicado: (2013)

Investigating the nature and quality of locally commissioned evaluations of the NHS Vanguard programme: an evidence synthesis
por: Wilson, Paul, et al.
Publicado: (2021)

The Vanguard of Community-based Integrated Care in Japan: The Effect of a Rural Town on National Policy
por: Hatano, Yu, et al.
Publicado: (2017)

Field safety study of VANGUARD®crLyme: A vaccine for the prevention of Lyme disease in dogs
por: Marconi, Richard T., et al.
Publicado: (2020)

Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome?
por: Moore, Hunter B., et al.
Publicado: (2020)

Patient Factors Associated With Attendance at a Comprehensive Postacute Stroke Visit: Insight From the Vanguard Site
por: Halladay, Jacqueline, et al.
Publicado: (2019)

Intraoperative oxygen concentration and neurocognition after cardiac surgery: study protocol for a randomized controlled trial
por: Shaefi, Shahzad, et al.
Publicado: (2017)

Blunt cerebrovascular injury in rugby and other contact sports: case report and review of the literature
por: Cuellar, Trajan A, et al.
Publicado: (2014)

Use of community-level data in the National Children’s Study to establish the representativeness of segment selection in the Queens Vanguard Site
por: Rundle, Andrew, et al.
Publicado: (2012)

VANGUARD®crLyme: A next generation Lyme disease vaccine that prevents B. burgdorferi infection in dogs
por: Marconi, Richard T., et al.
Publicado: (2020)

Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis
por: Choudhury, Rashikh, et al.
Publicado: (2020)

Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children’s Study
por: Stanford, Joseph B., et al.
Publicado: (2015)

Lessons learnt from the implementation of new care models in the NHS: a qualitative study of the North East Vanguards programme
por: Maniatopoulos, Gregory, et al.
Publicado: (2019)

Vanguard is a Glucose Deprivation‐Responsive Long Non‐Coding RNA Essential for Chromatin Remodeling‐Reliant DNA Repair
por: Zhang, Ben, et al.
Publicado: (2022)

Scale and spread of innovation in health and social care: Insights from the evaluation of the New Care Model/Vanguard programme in England
por: MacInnes, Julie, et al.
Publicado: (2023)

Thromboelastography‐guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: A systematic review and analysis
por: Dias, João D., et al.
Publicado: (2019)

A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK–Vanguard Study
por: Youle, Mike, et al.
Publicado: (2006)

A Technology-Based Intervention Among Young Men Who Have Sex With Men and Nonbinary People (The Conectad@s Project): Protocol for A Vanguard Mixed Methods Study
por: Torres, Thiago Silva, et al.
Publicado: (2022)

Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients
por: Stettler, Gregory R., et al.
Publicado: (2020)

Correction: A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK-Vanguard Study
Publicado: (2007)

Rationale and design of the impact of anticoagulation therapy on the Cognitive Decline and Dementia in Patients with Nonvalvular Atrial Fibrillation (CAF) Trial: A Vanguard study
por: Bunch, T. Jared, et al.
Publicado: (2019)

Complex programme evaluation of a ‘new care model’ vanguard: a shared commitment to quality improvement in an integrated health and care context
por: Fowler Davis, Sally, et al.
Publicado: (2020)

Transpulmonary pressure measurements and lung mechanics in patients with early ARDS and SARS-CoV-2
por: Baedorf Kassis, Elias, et al.
Publicado: (2021)

Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice
por: Puebla-Osorio, Nahum, et al.
Publicado: (2011)

User-Friendly Data-Sharing Practices for Fostering Collaboration within a Research Network: Roles of a Vanguard Center for a Community-Based Study
por: Lee, Jae Eun, et al.
Publicado: (2015)

Care home services at the vanguard: a qualitative study exploring stakeholder views on the development and evaluation of novel, integrated approaches to enhancing healthcare in care homes
por: Stocker, Rachel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_regev2mdbkcis3vs93j4f3ku5o