Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype

Prion diseases or prionoses are a group of rapidly progressing and invariably fatal neurodegenerative diseases. The pathogenesis of prionoses is associated with self-replication and connectomal spread of PrP(Sc), a disease specific conformer of the prion protein. Microglia undergo activation early i...

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Detalles Bibliográficos
Autores principales: Pankiewicz, Joanna E., Lizińczyk, Anita M., Franco, Leor A., Diaz, Jenny R., Martá-Ariza, Mitchell, Sadowski, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474943/
https://www.ncbi.nlm.nih.gov/pubmed/34565486
http://dx.doi.org/10.1186/s40478-021-01261-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474943/
https://www.ncbi.nlm.nih.gov/pubmed/34565486
http://dx.doi.org/10.1186/s40478-021-01261-z

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